Honest about the risks, and specific about what prevents each one.
Carrying the wrong medicine across the border
The Government of Canada states Zambia has very strict rules on importing medication and that certain prescription and over-the-counter drugs common in Canada are on the Zambian controlled-substances list. It asks travellers to check the legality of what they carry, and says an import permit may be required and should be obtained at least two weeks before travel. It also notes some prescription medications may not be available in Zambia.
Prevention Bring the real list of everything you take โ prescription and over-the-counter โ to the appointment, and do it early enough to leave two clear weeks. Carry everything in original labelled packaging in hand luggage, with enough for the whole trip.
Malaria
CDC lists transmission areas as all of Zambia, with chloroquine resistance and P. falciparum as the main parasite. CDC also warns that stopping the medicine too soon can still leave you ill, and that a fever while travelling or at any point up to a year after you return should send you for care. The Government of Canada recommends antimalarial medication for most travellers here.
Prevention Prescription tablets, chosen against your route and your other medicines โ and finished properly after you get home. Plus repellent, long sleeves at dusk and a treated net.
Fresh water
Both sources warn about schistosomiasis in Zambia and neither names a specific lake or river. CDC describes transmission through wading, swimming, bathing or washing in contaminated fresh water and says plainly not to swim in fresh, unchlorinated water such as lakes, ponds or rivers. The Government of Canada asks travellers to avoid contact with untreated fresh water. There is no vaccine and no preventive medication.
Prevention Treat all untreated fresh water as the same category, because that is how the guidance is written. Chlorinated pools are fine. If a swim is part of a booked activity, raise it with us before you go.
Roads
The Government of Canada describes major road safety issues in Zambia, with fatal accidents common โ naming the Great East Road, the Great North Road and Kafue Road specifically. Those are the main arteries a driving itinerary uses.
Prevention No intercity driving after dark. A driver from your lodge or operator on the long transfers. Seatbelts, including in the back.
Insect-borne illness beyond malaria
CDC names African sleeping sickness, African tick-bite fever, dengue and Rift Valley fever among what insects and animals carry in Zambia, along with leptospirosis, hantavirus and tuberculosis. African sleeping sickness is carried by tsetse flies, which is one reason repellent matters during the day and not only at dusk. The Government of Canada names dengue and chikungunya as present with sporadic or seasonal risk.
Prevention Repellent through the day, reapplied. Long trousers and closed shoes in grass and bush, and a tick check after a walking day. Permethrin-treated clothing for camping and walking safaris.
Animals and rabies
CDC says rabid dogs are commonly found in Zambia and rabies is present in some terrestrial wildlife, with treatment vaccines limited outside larger urban facilities. The Government of Canada also flags Rift Valley fever as an animal-contact risk. On safari the wildlife is managed by your guide; in towns it is the dogs, and children are the ones who approach them.
Prevention Do not touch or feed animals you do not know. Any bite, scratch or lick on broken skin: wash for fifteen minutes with soap and running water, then seek medical advice the same day. No unpasteurised milk.
Getting treated in a park
The Government of Canada says quality of care varies significantly across Zambia โ generally good in some private facilities in Lusaka, very limited or unavailable in rural areas โ and asks travellers to hold insurance covering medical evacuation and hospital stays.
Prevention Buy the insurance with evacuation cover and read what it actually covers. Save the policy number offline. Ask the camp itself, not the agent, what happens if somebody needs a hospital at short notice.