Honest about the risks, and specific about what prevents each one.
Malaria
Confined to the northeast. CDC recommends tablets for uMkhanyakude District in KwaZulu-Natal, Mopani and Vhembe in Limpopo, Ehlanzeni in Mpumalanga and Kruger National Park, and records transmission along the Mozambique and Zimbabwe borders. Mainly P. falciparum, with P. malariae, P. ovale and P. vivax less common, and chloroquine resistance is recorded.
Prevention Tablets for the four areas above, chosen against your dates and your other medicines. Bite prevention everywhere: repellent, covered skin at dusk, screened rooms or a treated net. And if fever appears up to a year after you get home, the Government of Canada asks you to see someone immediately and say where you have been.
Rabies โ including the seals
CDC says dogs infected with rabies are commonly found in South Africa and that it is present in some terrestrial wildlife, and there is a current outbreak in Cape fur seals in South Africa and Namibia. The Government of Canada notes rabies is almost always fatal once symptoms appear. Rabies vaccines are typically available across most of the country if an exposure happens.
Prevention Do not approach or touch seals, even where an operator says it is fine. No touching dogs, monkeys or baboons. Any bite, scratch or lick on broken skin: wash with soap and clean water for about fifteen minutes and get medical care the same day. If you are treated abroad, the Government of Canada asks you to keep written records and photos of the product labels and batch numbers, and to see someone here when you get back.
Schistosomiasis
A parasite in fresh water, named by both sources. The Government of Canada says most travellers are at low risk, that the worms break the skin, and that there is no vaccine and no medication to prevent infection. CDC lists streams, rivers, ponds, lakes and untreated pools.
Prevention No wading, swimming, bathing or washing in fresh water โ the whole strategy is staying out. Chlorinated pools and the sea are fine. The Government of Canada adds a smaller point: try not to get freshwater in your eyes, mouth or nose, especially after heavy rain, because water that looks clean may not be.
Ticks
CDC lists both African tick-bite fever and Crimean-Congo haemorrhagic fever for South Africa, both from tick bites, and the Government of Canada adds that CCHF risk is generally low for most travellers and there is no vaccine. Bush walks, long grass and game farms are where this happens, which is exactly what a walking safari is.
Prevention A repellent with 20% or more DEET, which CDC specifies for ticks as well as mosquitoes. Permethrin-treated clothing, socks and closed shoes, and a full body tick check after every outdoor day โ including on children and gear.
The roads
The Government of Canada says fatal road accidents are common and often involve pedestrians, that drivers frequently ignore traffic laws and speed, that drinking and driving is common, and that travel on foot is inadvisable in most areas. Roads are good around the cities and poor in remote areas โ potholes, bad lighting, stray animals, people crossing highways. CDC names motor vehicle crashes the number one killer of healthy travellers abroad, notes traffic drives on the left, and advises against driving at night because street lighting can be poor.
Prevention No driving after dark. Traffic lights that are out should be treated as a four-way stop. Seatbelts including in the back, a rental company with 24-hour emergency service, and a route planned in advance rather than whatever the GPS suggests โ the Government of Canada warns the most direct route is not always the safest.
Crime
The whole advisory rests on this: a high degree of caution because of the significant level of serious crime. Violent crime occurs throughout the country and has involved foreigners. Carjackings and armed robberies are common after dark, with windows smashed at traffic lights and off-ramps. There are also warnings about theft from hotel rooms, express kidnappings from taxis and ride-shares, and food or drink being spiked.
Prevention Keep windows up and doors locked while driving. Avoid city centres after dark and townships you do not know. Arrange airport transfers in advance and travel in daylight. If you are robbed, the Government of Canadaโs advice is to comply immediately and not resist.
Wildlife and the parks
The Government of Canada is direct about it: wild animals are dangerous, particularly on foot or at close range, and baboons in particular will confront people for food and can overwhelm them. Many parks and reserves are remote with limited emergency services, and animals wander into camps.
Prevention Only leave the vehicle when a guide or warden says so. Do not walk around camp at night, and never leave children unattended. Use reputable, professional guides and follow park rules โ including the ones that feel excessive.
Getting treated
The Government of Canada says the quality of care varies significantly across the country and that good medical care is generally available only in major cities. Private hospitals are expensive, require proof of insurance and often ask for immediate payment. Emergency services are slow outside major centres and air evacuation may be the only option in remote areas โ which is a plain description of the lowveld and most game reserves. It also notes some prescription medicines may not be available in South Africa.
Prevention Travel insurance that covers medical evacuation and hospital stays, with the policy number saved offline rather than only in email. Bring enough of your own medication for the whole trip in its original container with a copy of the prescription, in your carry-on.